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科学家发现可能导致阿尔茨海默病的新蛋白质_我的网站

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一 | Arnold Schwarzenegger has been accused of some really rude behavior on set by actress Miriam Margolyes, who claimed that the Terminator icon "deliberately farted" right in her face.,The actress made the claim on the latest episode of the ‘I’ve Got News for You’ podcast, saying that Schwarzenegger, with whom she worked on the 1999 horror movie ‘End of Days’, was "actually quite rude".,Apart from being rude, Margolyes claims that Schwarzenegger was "a bit too full of himself" back at the time.,“I was playing Satan’s sister, and he was killing me, so he had me in a position where I couldn’t escape and lying on the floor. And he just farted," she said. "It wasn’t on film, it was in one of the pauses, but I haven’t forgiven him for it.",'End of Days' premiered in November 1999, following the story of a former New York Police Department detective Jericho Cane, portrayed by Schwarzenegger, who finds himself in the middle of a religious conflict and has to protect a woman chosen by evil forces to conceive Satan.。阿尔茨海默病（AD）是一种使人衰弱的渐进性疾病，开始时是轻微的记忆丧失，慢慢地破坏了认知功能和记忆。

二 | 它目前没有治愈方法，预计到2050年将影响全球1亿多人。在美国，根据国家老龄化研究所的数据，AD是老年人痴呆的主要原因，也是第七大最常见的死亡原因。正在进行的阿尔茨海默氏症研究集中在两个关键的神经毒性蛋白上：淀粉样β（Aβ）和tau。尽管这些蛋白质已被证明与AD有关，但Aβ和tau的水平并不能持续解释或与一些疾病患者的认知能力下降的严重程度相关。作为麻省总医院布里格姆医疗系统的创始成员之一，布里格姆妇女医院的研究人员着手确定其他可能直接参与AD基本方面的蛋白质，如突触损失和神经变性。

三 | 他们将实验室的神经元暴露在大约40人的大脑提取物中，这些人要么患有AD，要么在Aβ和tau水平较高的情况下受到保护，要么在大脑中很少或没有Aβ和tau时受到保护。科学家们发现并验证了神经节苷脂GM2激活剂（GM2A）是一种能够减少神经元发射并诱发神经元完整性丧失的蛋白质。这些蛋白质的特征可能有助于AD的病因、疾病的进展，或两者都有。高级作者、神经学系的Tracy Young-Pearse博士说："我们的数据有助于确定一种可能与阿尔茨海默病的发病机制有关的新的和潜在的重要蛋白质。有趣的是，GM2A以前被认为是一种与Tay-Sachs病非常相似的溶酶体储存障碍的致病因素，Tay-Sachs病是另一种像AD一样破坏神经元的疾病。

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Published on:10:53:41

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